Endocrine Abstracts

Introduction: It is universally accepted that calcitonin (CT), a hormone secreted by the parafollicular cells of the thyroid, is a specific, sensitive and early marker of Medullary Thyroid Carcinoma (CMT), with higher diagnostic accuracy than fine needle aspiration biopsy(FNAB). However, the routine measurement of serum CT during assessment of nodular thyroid disease (NTD) remains controversial due to rarity of this cancer and possible false positive results.<p class="abst...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcemia due to an unregulated overproduction of parathyroid hormone (PTH). PHPT is most commonly caused by a single adenoma of the parathyroid gland, usually located just behind the thyroid gland. However, in rare cases, they can have an ectopic location, including intrathyroid adenomas. In some cases, the measurement of intact PTH in the wash out fluid obtained by US-Fine Ne...

Introduction: Dyslipidemia (DL) in diabetic patients is frequently undertreated. Even when cLDL targets have not been met, treatment remains unchanged despite the availability of alternatives approaches. This is known as therapeutic inertia (TI).The aim of this study was to evaluate the prevalence of TI in lipid management among diabetic patients and to analyse associated factors and possible causes.Material and Methods: Retrospective, cross-sectional st...

PATZ1, a member of the POZ-ZF protein family of transcription factors is emerging as an important cancer-associated factor that can act either as oncogene or tumour-suppressor depending on the cellular context. Consistent with a tumour-suppressor role in thyroid cells, we have shown that PATZ1 is highly downregulated in anaplastic thyroid carcinomas compared to normal thyroid tissue and is a powerful inhibitor of anaplastic thyroid cancer cell survival, migration, invasiveness...

Introduction: Liraglutide, a GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the efficacy and safety of liraglutide in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). All patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatment, or patients intole...

Protein kinase C (PKC) is a family of serine-threonine kinases that regulate many cellular processes including proliferation and survival. Previous evidence has shown that PKC is involved in the control of human medullary thyroid carcinoma (MTC) proliferation and survival by modulating apoptosis, with a mechanism that implicates PKCβII isoform and translocation in different subcellular compartments.In this study, we investigated the role of PKC&#948...

Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were incl...

Aim: To evaluate the relationship between autoimmune thyroiditis (AIT), subclinical hypothyroidism (SCH) and cardiovascular risk factors.Patients and methods: We recorded thyroid function tests, BMI, insulin resistance markers comprising the homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body insulin sensitivity index (WBI...

Background: Osteogenesis imperfecta (OI) is a few frequent disease with abnormal synthesis of type 1 collagen. That affects skeletal but also extra-skeletal tissues. Aortic root (AR) dilatation and valvular dysfunction have been described. Other studies, to estimate the size of the AR, index it by the body surface area (BSA), however, although these patients are shorter their internal organs have a relatively normal growth, so we could find overestimated AR values. Therefore, ...

Introduction: Although involved in feeding and weight homeostasis, stimulation of pituitary GH secretion is the best established action of stomach-produced hormone ghrelin. However, its role in regulation of GH secretion is not yet clear. Some evidence indicates that circulating concentrations of GH and/or IGF-I could influence ghrelin levels. The pathophysiology of ghrelin secretion in acromegaly (specially aftar an oral glucose tolerance test (OGTT) is unclear.<p class="...